High throughput screening identifies potential inhibitors targeting trimethoprim resistant DfrA1 protein in Klebsiella pneumoniae and Escherichia coli

High throughput screening identifies potential inhibitors targeting trimethoprim resistant DfrA1 protein in Klebsiella pneumoniae and Escherichia coli

Abstract The DfrA1 protein provides trimethoprim resistance in bacteria, especially Klebsiella pneumoniae and Escherichia coli, by modifying dihydrofolate reductase, which reduces the binding efficacy of the antibiotic. This study identified inhibitors of the trimethoprim-resistant DfrA1 protein thr...

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Main Authors: Soharth Hasnat, Soaibur Rahman, Meherun Binta Alam, Farha Mohi Suin, Farzana Yeasmin, Tanjila Suha, Nahuna Tanjin Supty, Sal Sabila, Animesh Chowdhury, A. D. A. Shahinuzzaman, M. Murshida Mahbub, Tofazzal Islam, M. Nazmul Hoque
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Trimethoprim
Antimicrobial resistance
DfrA1
Inhibitors
High-throughput screening
Computational drug discovery
Online Access:https://doi.org/10.1038/s41598-025-91410-4
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https://doi.org/10.1038/s41598-025-91410-4

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