Effect of a FOXO1 inhibitor on trophoblast differentiation from human pluripotent stem cells and ERV-associated gene expression

Effect of a FOXO1 inhibitor on trophoblast differentiation from human pluripotent stem cells and ERV-associated gene expression

Introduction: In human placental development, the trophectoderm (TE) appears in blastocysts on day 5 post-fertilization and develops after implantation into three types of trophoblast lineages: cytotrophoblast (CT), syncytiotrophoblast (ST), and extravillous trophoblast (EVT). CDX2/Cdx2 is expressed...

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Bibliographic Details
Main Authors: Erika Tanaka, Michiyo Koyanagi-Aoi, So Nakagawa, Sayumi Shimode, Hideto Yamada, Yoshito Terai, Takashi Aoi
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Regenerative Therapy
Subjects:
CDX2
Induced pluripotent stem cells
Trophectoderm
Trophoblast
Endogenous retrovirus
FOXO1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320424001561
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