Enhanced mutanome analysis towards the induction of neoepitope-reactive T-cell responses for personalized immunotherapy of pancreatic cancer

Enhanced mutanome analysis towards the induction of neoepitope-reactive T-cell responses for personalized immunotherapy of pancreatic cancer

Background Personalized immunotherapy of pancreatic ductal adenocarcinoma (PDAC) through T-cell mediated targeting of tumor-specific, mutanome-encoded neoepitopes may offer new opportunities to combat this disease, in particular by countering recurrence after primary tumor resection. However, the se...

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Main Authors: Oliver Strobel, Isabel Poschke, Rienk Offringa, Thomas Blankenstein, Claudia Lauenstein, Andreas Trumpp, Gerald Willimsky, Michael Volkmar, Dana Hoser, Janina Rebmann, Agnes Hotz-Wagenblatt, Jan Rieger, Jonas P Becker, Angelika B Riemer, Martin Sprick
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e011802.full
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https://jitc.bmj.com/content/13/6/e011802.full

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