Combining chemotherapeutic agents and netrin‐1 interference potentiates cancer cell death

Combining chemotherapeutic agents and netrin‐1 interference potentiates cancer cell death

Abstract The secreted factor netrin‐1 is upregulated in a fraction of human cancers as a mechanism to block apoptosis induced by netrin‐1 dependence receptors DCC and UNC5H. Targeted therapies aiming to trigger tumour cell death via netrin‐1/receptors interaction interference are under preclinical e...

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Bibliographic Details
Main Authors: Andrea Paradisi, Marion Creveaux, Benjamin Gibert, Guillaume Devailly, Emeline Redoulez, David Neves, Elsa Cleyssac, Isabelle Treilleux, Christian Klein, Gerhard Niederfellner, Philippe A. Cassier, Agnès Bernet, Patrick Mehlen
Format: Article
Language:English
Published: Springer Nature 2013-10-01
Series:EMBO Molecular Medicine
Subjects:
cancer therapy
DCC
dependence receptor
netrin‐1, p53
Online Access:https://doi.org/10.1002/emmm.201302654
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https://doi.org/10.1002/emmm.201302654

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