Insights into the E2F target genes in breast cancer: associations of pathway genes with prognosis and immune cell filtration based on in silico and ex vivo analyses

Insights into the E2F target genes in breast cancer: associations of pathway genes with prognosis and immune cell filtration based on in silico and ex vivo analyses

Abstract Background E2F transcription factors are crucial in various biological processes, including cell proliferation, differentiation, and apoptosis. However, the exact role of E2F target genes in breast cancer (BC), as well as their influence on survival and immune response, remains poorly under...

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Bibliographic Details
Main Authors: Behnoosh Nikonezhad, Maryam Lotfian, Nadia Manavi, Atefeh Zamani, Mohammad Mahdevar
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer Cell International
Subjects:
E2F transcription factors
Breast cancer
Prognosis
Immune cell infiltration
Gene expression
Single cell
Online Access:https://doi.org/10.1186/s12935-025-03839-2
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https://doi.org/10.1186/s12935-025-03839-2

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