Vancomycin‐intermediate Staphylococcus aureus employs CcpA‐GlmS metabolism regulatory cascade to resist vancomycin

Vancomycin‐intermediate Staphylococcus aureus employs CcpA‐GlmS metabolism regulatory cascade to resist vancomycin

Abstract Vancomycin (VAN)‐intermediate Staphylococcus aureus (VISA) is a critical cause of VAN treatment failure worldwide. Multiple genetic changes are reportedly associated with VISA formation, whereas VISA strains often present common phenotypes, such as reduced autolysis and thickened cell wall....

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Main Authors: Huagang Peng, Yifan Rao, Weilong Shang, Yi Yang, Li Tan, Lu Liu, Zhen Hu, Yuting Wang, Xiaonan Huang, He Liu, Mengyang Li, Zuwen Guo, Juan Chen, Yuhua Yang, Jianghong Wu, Wenchang Yuan, Qiwen Hu, Xiancai Rao
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:MedComm – Future Medicine
Subjects:
catabolite control protein A
metabolic changes
Staphylococcus aureus
two‐component system
vancomycin resistance
Online Access:https://doi.org/10.1002/mef2.70007
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https://doi.org/10.1002/mef2.70007

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