Protoporphyrin IX plasma and blood pharmacokinetics and brain tumor distribution determined by a validated LC–MS/MS method

Protoporphyrin IX plasma and blood pharmacokinetics and brain tumor distribution determined by a validated LC–MS/MS method

Abstract Protoporphyrin IX (PPIX) is a fluorescent metabolite in the heme biosynthesis pathway, and cancer cells accumulate it when 5-aminolevulinic acid (5-ALA), a precursor, is administered. In the U.S., 5-ALA is approved for visualizing high-grade gliomas (HGG) during fluorescence-guided surgery....

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Bibliographic Details
Main Authors: William Knight, Tigran Margaryan, Kamal Shaik, Nader Sanai, Artak Tovmasyan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Protoporphyrin IX (PPIX)
Liquid chromatography tandem mass spectrometry (LC–MS/MS)
5-aminolevulinic acid (5-ALA)
Sonodynamic therapy
Brain tumor
Photodynamic therapy
Online Access:https://doi.org/10.1038/s41598-025-05780-w
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https://doi.org/10.1038/s41598-025-05780-w

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