Nifuroxazide and 4-Hydroxybenzhydrazone Derivatives as New Antiparasitic (<i>Trypanosoma cruzi</i> and <i>Leishmania mexicana</i>) and Anti-<i>Mycobacterium tuberculosis</i> Agents

Nifuroxazide and 4-Hydroxybenzhydrazone Derivatives as New Antiparasitic (<i>Trypanosoma cruzi</i> and <i>Leishmania mexicana</i>) and Anti-<i>Mycobacterium tuberculosis</i> Agents

<b>Background/Objectives:</b> Nifuroxazide (Nfz) is a drug that has been used as a scaffold for designing antimicrobial and antiparasitic agents. This study aimed to synthesize and evaluate in vitro of Nfz and twenty-five 4-hydroxybenzhydrazone derivatives as potential anti-<i>Tryp...

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Main Authors: Timoteo Delgado-Maldonado, Diana V. Navarrete-Carriola, Lenci K. Vázquez-Jiménez, Alma D. Paz-González, Baojie Wan, Scott Franzblau, Othman Mueen Mohammed, Lorena Rodríguez-Páez, Charmina Aguirre-Alvarado, Verónica Alcántara-Farfán, Joaquín Cordero-Martínez, Debasish Bandyopadhyay, Adriana Moreno-Rodríguez, Gildardo Rivera
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
hydrazone moiety
nifuroxazide
cysteine protease inhibitors
<i>Leishmania mexicana</i>
<i>Trypanosoma cruzi</i>
anti-<i>Mycobacterium tuberculosis</i>
Online Access:https://www.mdpi.com/1999-4923/17/5/621
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