Characterization of immune microenvironment associated with medulloblastoma metastasis based on explainable machine learning

Characterization of immune microenvironment associated with medulloblastoma metastasis based on explainable machine learning

ABSTRACT Importance Medulloblastoma (MB) is the most common malignant brain tumor in children, with metastasis being the primary cause of recurrence and mortality. The tumor microenvironment (TME) plays a critical role in driving metastasis; however, the mechanisms underlying TME alterations in MB m...

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Bibliographic Details
Main Authors: Fengmao Zhao, Xiangjun Liu, Jingang Gui, Hailang Sun, Nan Zhang, Yun Peng, Ming Ge, Wei Wang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Pediatric Investigation
Subjects:
CD8+ T lymphocytes
Machine learning
Medulloblastoma
Metastasis
Transforming growth factor beta 1
Online Access:https://doi.org/10.1002/ped4.12471
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https://doi.org/10.1002/ped4.12471

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