Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes

Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes

Abstract The myocyte enhancer factor 2 (MEF2) regulates transcription in cardiac myocytes and adverse remodeling of adult hearts. Activators of G protein‐coupled receptors (GPCRs) have been reported to activate MEF2, but a comprehensive analysis of GPCR activators that regulate MEF2 has to our knowl...

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Main Authors: András D Tóth, Richard Schell, Magdolna Lévay, Christiane Vettel, Philipp Theis, Clemens Haslinger, Felix Alban, Stefanie Werhahn, Lina Frischbier, Jutta Krebs‐Haupenthal, Dominique Thomas, Hermann‐Josef Gröne, Metin Avkiran, Hugo A Katus, Thomas Wieland, Johannes Backs
Format: Article
Language:English
Published: Springer Nature 2018-06-01
Series:EMBO Molecular Medicine
Subjects:
histone deacetylase 5
myocyte enhancer factor 2
p21‐activated kinase 2
prostaglandin E2
protein kinase D
Online Access:https://doi.org/10.15252/emmm.201708536
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https://doi.org/10.15252/emmm.201708536

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