Position Matters: Effect of Nitro Group in Chalcones on Biological Activities and Correlation via Molecular Docking

Position Matters: Effect of Nitro Group in Chalcones on Biological Activities and Correlation via Molecular Docking

A series of nine nitro group-containing chalcones were synthesized to investigate their anti-inflammatory and vasorelaxant activities via in vivo, ex vivo, and in silico studies. The anti-inflammatory effects of the compounds were evaluated via a TPA-induced mouse ear edema model, and the vasorelaxa...

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Main Authors: Alam Yair Hidalgo, Nancy Romero-Ceronio, Carlos Ernesto Lobato-García, Maribel Herrera-Ruiz, Romario Vázquez-Cancino, Omar Aristeo Peña-Morán, Miguel Ángel Vilchis-Reyes, Ammy Joana Gallegos-García, Eric Jaziel Medrano-Sánchez, Oswaldo Hernández-Abreu, Abraham Gómez-Rivera
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Scientia Pharmaceutica
Subjects:
chalcones
nitro group
anti-inflammatory activity
vasorelaxant activity
docking
Online Access:https://www.mdpi.com/2218-0532/92/4/54
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