Integrating bulk and single-cell RNA sequencing reveals intratumor heterogeneity phenotypes and immune infiltration in pancreatic cancer

Abstract Background Although the significance of intratumoral heterogeneity (ITH) has been widely acknowledged in various cancers, its role in pancreatic cancer (PC) remains underexplored and warrants further investigation. Methods Pancreatic cancer transcriptomic data were acquired from the TCGA an...

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Bibliographic Details
Main Authors: Li Zhao, Yao Huang, Jiang Li, Rui Xie, Kaiming Li
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
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Online Access:https://doi.org/10.1007/s12672-025-03080-3
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