RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway

RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway

Background: Osteoarthritis (OA) is a degenerative joint disease that remains challenging to treat due to lack of complete understanding of its pathogenesis. Previous studies have identified RO5126766 (RO) as a small molecule compound that inhibited RAF/MEK-ERK pathway and garnered much interest for...

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Main Authors: Han Wang, Xiwen Yuan, Jie Han, Zuoxing Wu, Zheru Ma, Fan Shi, Zhengqiong Luo, Zihan Chen, Chenyang Guo, Guixin Yuan, Xuemei He, Zemin Ling, Lin Meng, Rong Shen, Jianming Huang, Ren Xu
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Orthopaedic Translation
Subjects:
Chondrocyte
Degeneration
ERK pathway
Osteoarthritis
Osteoclast differentiation
RO5126766
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X25000336
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