Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia

Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia

Abstract Children and adults with 22q11.2 deletion syndrome (22q11.2DS) experience cognitive and emotional challenges and face a markedly increased risk for schizophrenia (SCZ), yet how this deletion alters early human brain development remains unclear. Using cerebral cortex organoids derived from i...

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Main Authors: Sneha B. Rao, Zhixiong Sun, Francesco Brundu, Yannan Chen, Yan Sun, Huixiang Zhu, Robert J. Shprintzen, Raju Tomer, Raul Rabadan, Kam W. Leong, Sander Markx, Steven A. Kushner, Bin Xu, Joseph A. Gogos
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62187-x
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https://doi.org/10.1038/s41467-025-62187-x

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