A combined mathematical and experimental approach reveals the drivers of time-of-day drug sensitivity in human cells

Abstract The circadian clock plays a pivotal role in regulating various aspects of cancer, influencing tumor growth and treatment responses. There are significant changes in drug efficacy and adverse effects when drugs are administered at different times of the day, underscoring the importance of co...

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Bibliographic Details
Main Authors: Nica Gutu, Hitoshi Ishikuma, Carolin Ector, Ulrich Keilholz, Hanspeter Herzel, Adrián E. Granada
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07931-1
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