Influence of DNA-binding compounds with cancer preventive activity on the mechanisms of gene expression regulation

Influence of DNA-binding compounds with cancer preventive activity on the mechanisms of gene expression regulation

The presented review is devoted to the analysis of molecular mechanisms of action for different natural DNA-tropic compounds with established tumor preventive activity. Here we present their cancer preventive effects observed in vivo, mechanisms of DNA binding, influence on epigenetic regulation and...

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Main Authors: K. I. Kirsanov, O. A. Vlasova, T. I. Fetisov, R. G. Zenkov, E. A. Lesovaya, G. A. Belitsky, K. Gurova, M. G. Yakubovskaya
Format: Article
Language:Russian
Published: ABV-press 2019-01-01
Series:Успехи молекулярной онкологии
Subjects:
dna-tropic secondary plant metabolites
cancer preventive activity of natural small molecules
dna intercalation
epigenetic regulation of gene expression
chromatin destabilization
Online Access:https://umo.abvpress.ru/jour/article/view/173
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