Overcoming dengue vaccine challenges through next-generation virus-like particle immunization strategies

Overcoming dengue vaccine challenges through next-generation virus-like particle immunization strategies

Dengue fever represents an escalating global health threat, as unprecedented outbreaks expose significant limitations of current vaccine strategies. Conventional live-attenuated dengue vaccines, while partially efficacious, face critical hurdles including serotype imbalances and antibody-dependent e...

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Bibliographic Details
Main Authors: Mariana Parra-González, Lucio Nájera-Maldonado, Esperanza Peralta-Cuevas, Ashley J. Gutierrez-Onofre, Igor Garcia-Atutxa, Francisca Villanueva-Flores
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
dengue virus
virus-like particle
vaccine
antibody-dependent enhancement (ADE)
immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1614805/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1614805/full

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