microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism

microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism

Objective: Metabolic flexibility refers to the ability of tissues to adjust cellular fuel choice in response to conditional changes in metabolic demand and activity. A loss of metabolic flexibility is a defining feature of various diseases and cellular dysfunction. This study investigated the role o...

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Main Authors: Ahmed Ismaeel, Bailey D. Peck, McLane M. Montgomery, Benjamin I. Burke, Jensen Goh, Abigail B. Franco, Qin Xia, Katarzyna Goljanek-Whysall, Brian McDonagh, Jared M. McLendon, Pieter J. Koopmans, Daniel Jacko, Kirill Schaaf, Wilhelm Bloch, Sebastian Gehlert, Kevin A. Murach, Kelsey H. Fisher–Wellman, Ryan L. Boudreau, Yuan Wen, John J. McCarthy
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular Metabolism
Subjects:
eCLIP-seq
Aerobic glycolysis
PKM
MCT4
VB124
Resistance training
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000894
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