Arachidonic acid is involved in high-salt diet-induced coronary remodeling through stimulation of the IRE1α/XBP1s/RUNX2/OPN signaling cascade

Arachidonic acid is involved in high-salt diet-induced coronary remodeling through stimulation of the IRE1α/XBP1s/RUNX2/OPN signaling cascade

Abstract Background The impact of a high-salt (HS) diet on metabolic disturbances in individuals with coronary heart disease remains unclear. The arachidonic acid (AA) metabolic pathway is closely linked to the development of cardiometabolic diseases and atherosclerotic cardiovascular diseases. Furt...

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Bibliographic Details
Main Authors: Zhuoran Jia, Jian Wu, Fang Liu, Huimin Wang, Peiyang Zheng, Bing Shen, Ren Zhao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Lipids in Health and Disease
Subjects:
Arachidonic acid
High-salt diet
Coronary artery smooth muscle cells
Endoplasmic reticulum stress
Osteopontin
Phenotypic transformation
Online Access:https://doi.org/10.1186/s12944-025-02465-1
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https://doi.org/10.1186/s12944-025-02465-1

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