Hypomethylation of the Soluble Fms-like Tyrosine Kinase 1 (sFlt-1) Gene Promoter Region and Elevated sFlt-1 Placental Expression as Risk Factors for Preeclampsia

Hypomethylation of the Soluble Fms-like Tyrosine Kinase 1 (sFlt-1) Gene Promoter Region and Elevated sFlt-1 Placental Expression as Risk Factors for Preeclampsia

BACKGROUND: Preeclampsia significantly contributes to maternal and fetal morbidity and mortality worldwide, marked by an imbalance of angiogenic factors, particularly increased soluble Fms-like tyrosine kinase-1 (sFlt-1), leading to endothelial dysfunction. Epigenetic regulation, including DNA methy...

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Bibliographic Details
Main Authors: Anak Agung Ngurah Jaya Kusuma, I Made Darmayasa, I Gede Mega Putra, Anom Suardika, Evert Solomon Pangkahila, Vidya Saraswati Putri Duarsa, William William
Format: Article
Language:English
Published: Secretariat of The Indonesian Biomedical Journal 2025-08-01
Series:Indonesian Biomedical Journal
Online Access:https://inabj.org/index.php/ibj/article/view/3744
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https://inabj.org/index.php/ibj/article/view/3744

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