Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway

Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway

Alcohol-associated liver disease (ALD) is a prevalent global health issue primarily caused by excessive alcohol consumption. Recent studies have highlighted the gut-liver axis’s protective role against ALD, mainly through gut microbiota. However, the precise mechanism remains ill-defined. Our result...

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Main Authors: Hejiao Zhang, Qiang Hu, Yong Zhang, Lei Yang, Shanfei Tian, Xinru Zhang, Haiyuan Shen, Hang Shu, Linxi Xie, Dongqing Wu, Liangliang Zhou, Xiaoli Wei, Chen Cheng, Jiali Jiang, Hua Wang, Cailiang Shen, Derun Kong, Long Xu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Alcohol-associated liver disease
Lachnospiraceae bacterium
N-Acetyl-glutamic acid
NRF2
ferroptosis
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2517821
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https://www.tandfonline.com/doi/10.1080/19490976.2025.2517821

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