Impact of dapagliflozin on metabolic phenotype, hormone levels, and fertility in female mice after prolonged high-fat diet

Impact of dapagliflozin on metabolic phenotype, hormone levels, and fertility in female mice after prolonged high-fat diet

IntroductionA long-term high-fat diet (HFD) cause obesity and infertility through hypothalamic inflammation and insulin resistance, leading to metabolic abnormalities and ovulation dysfunction. The sodium-glucose cotransporter 2 inhibitors (SGLT2i) have emerged as a treatment for type 2 diabetic pat...

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Bibliographic Details
Main Authors: Xiaolin Chen, Zhuoni Xiao, Na Dai, Mingxia Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Endocrinology
Subjects:
sodium-glucose cotransporter 2
metabolism
insulin resistance
reproductive function
high-fat diet
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1457268/full
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