Deleting adipose FXR exacerbates metabolic defects and induces endocannabinoid lipid, 2-oleoyl glycerol, in obesity

Deleting adipose FXR exacerbates metabolic defects and induces endocannabinoid lipid, 2-oleoyl glycerol, in obesity

The nutrient sensor farnesoid X receptor (FXR) transcriptionally regulates whole-body lipid and glucose homeostasis. Several studies examined targeting FXR as a modality to treat obesity with varying conflicting results, emphasizing the need to study tissue-specific roles of FXR. We show that deleti...

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Bibliographic Details
Main Authors: Weinan Zhou, Sarith R. Bandara, Kyungwon Ko, Oludemilade Akinrotimi, Diego Hernández-Saavedra, Emily Richter, Noah Brauer, Taylor J. Woodward, Heather B. Bradshaw, Cecilia Leal, Sayeepriyadarshini Anakk
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Lipid Research
Subjects:
obesity
FXR
adipose tissue
FAAH
endocannabinoid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000148
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