Huperzine A Production and Acetylcholinesterase Inhibition by <i>Phlegmariurus taxifolius</i> Cell Suspension Culture: A Comparative Study in Flasks and an Airlift Bioreactor

Huperzine A Production and Acetylcholinesterase Inhibition by <i>Phlegmariurus taxifolius</i> Cell Suspension Culture: A Comparative Study in Flasks and an Airlift Bioreactor

<b>Background</b>: The callus cultures from the fronds of the lycophyte <i>Phlegmariurus taxifolius</i> produce the huperzine A (HupA) alkaloid, which is used in Alzheimer’s disease treatment. This study aimed to establish the growth kinetics and HupA production by the newly...

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Main Authors: Rocío del Carmen Pérez Aguilar, Talia Rodríguez Salgado, Olga Lidia Cruz-Miranda, Alexis Uriel Soto Díaz, Ariadna Zenil Rodríguez, Lamine Bensaddek, Christian Carreño-Campos, María Luisa Villarreal, Anabel Ortiz-Caltempa, Alexandre Toshirrico Cardoso-Taketa
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceuticals
Subjects:
<i>Phlegmariurus taxifolius</i>
Lycopodiaceae
huperzine A
cell culture
250 mL flasks
2 L airlift bioreactor
Online Access:https://www.mdpi.com/1424-8247/18/3/383
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