Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space

Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space

Abstract α-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity. To disentangle the consequences of neuronal loss versu...

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Bibliographic Details
Main Authors: J. Estaun-Panzano, S. Nandi, Q. Gresil, E. Doudnikoff, C. Mazzocco, ML. Arotcarena, MH. Canron, B. Dehay, L. Cognet, E. Bezard
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00850-8
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