The role of factor V in trauma-induced coagulopathy: an observational and experimental study

The role of factor V in trauma-induced coagulopathy: an observational and experimental study

Background: In bleeding patients with trauma-induced coagulopathy (TIC), factor (F)V becomes depleted, which may not be corrected with existing treatment strategies. It is currently unknown whether supplementing FV or FVa improves TIC. Objectives: To explore the relationship between FV activity and...

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Main Authors: Pieter H. Sloos, Romein W.G. Dujardin, Joost C.M. Meijers, Christine Gaarder, Ross Davenport, Simon Stanworth, Pär I. Johansson, Jakob Stensballe, Marc Maegele, Nicole P. Juffermans, Derek J.B. Kleinveld
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
hemostasis
blood coagulation factors
factor V
wounds and Injuries
hemorrhage
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037925001815
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