C-X-C motif chemokine ligand 12—C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules

C-X-C motif chemokine ligand 12—C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules

Chemokines are small, secreted cytokines crucial in the regulation of a variety of cell functions. The binding of chemokine C-X-C motif chemokine ligand 12 (CXCL12) (stromal cell-derived factor 1) to a G-protein-coupled receptor C-X-C chemokine receptor type 4 (CXCR4) triggers downstream signaling p...

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Bibliographic Details
Main Authors: Jui-Hung Yen, Chun-Chun Chang, Hao-Jen Hsu, Chin-Hao Yang, Hemalatha Mani, Je-Wen Liou
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-05-01
Series:Tzu Chi Medical Journal
Subjects:
cancer progression
chemotherapeutic agents
cxcl12
cxcr4
stromal cell-derived factor 1
Online Access:https://journals.lww.com/10.4103/tcmj.tcmj_52_24
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