Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On-Demand
Objectives. Haemophilia A is a congenital disorder of coagulation that mainly affects males and causes a considerable use of resources, especially when hemophilic patients are treated with prophylaxis. The aim of the present review was to discuss and appraise the methodological aspects and results o...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/596164 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551130784071680 |
|---|---|
| author | Brigid Unim Maria Assunta Veneziano Antonio Boccia Walter Ricciardi Giuseppe La Torre |
| author_facet | Brigid Unim Maria Assunta Veneziano Antonio Boccia Walter Ricciardi Giuseppe La Torre |
| author_sort | Brigid Unim |
| collection | DOAJ |
| description | Objectives. Haemophilia A is a congenital disorder of coagulation that mainly affects males and causes a considerable use of resources, especially when hemophilic patients are treated with prophylaxis. The aim of the present review was to discuss and appraise the methodological aspects and results of published economic evaluations of haemophilia A treatments in the last decade. Methods. The literature search, performed by consulting four engines, covered studies published between 2002 and 2014. Full economic evaluations published in English language were identified and included in the review. A quality assessment of the studies was also carried out based on Drummond’s checklist. Results. After careful evaluations of the identified records, 5 studies were reviewed. Primary and secondary prophylaxis resulted cost-effective compared to on-demand therapy: the ICER of primary prophylaxis ranged from €40.236 to €59.315/QALY gained, while the ICER of secondary prophylaxis was €40.229/QALY gained. Furthermore, 60% were high quality and 40% were medium quality studies. Conclusions. The review underlines the cost-effectiveness of prophylaxis versus on-demand treatment and the different methodological approaches applied. Further economic evaluations are required with models that reflect the clinical reality and consumption of resources in each country. |
| format | Article |
| id | doaj-art-9ce5bbedcc8f45559c5c4e56d0bcfd97 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9ce5bbedcc8f45559c5c4e56d0bcfd972025-02-03T06:04:55ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/596164596164Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On-DemandBrigid Unim0Maria Assunta Veneziano1Antonio Boccia2Walter Ricciardi3Giuseppe La Torre4Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyInstitute of Hygiene, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyInstitute of Hygiene, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyObjectives. Haemophilia A is a congenital disorder of coagulation that mainly affects males and causes a considerable use of resources, especially when hemophilic patients are treated with prophylaxis. The aim of the present review was to discuss and appraise the methodological aspects and results of published economic evaluations of haemophilia A treatments in the last decade. Methods. The literature search, performed by consulting four engines, covered studies published between 2002 and 2014. Full economic evaluations published in English language were identified and included in the review. A quality assessment of the studies was also carried out based on Drummond’s checklist. Results. After careful evaluations of the identified records, 5 studies were reviewed. Primary and secondary prophylaxis resulted cost-effective compared to on-demand therapy: the ICER of primary prophylaxis ranged from €40.236 to €59.315/QALY gained, while the ICER of secondary prophylaxis was €40.229/QALY gained. Furthermore, 60% were high quality and 40% were medium quality studies. Conclusions. The review underlines the cost-effectiveness of prophylaxis versus on-demand treatment and the different methodological approaches applied. Further economic evaluations are required with models that reflect the clinical reality and consumption of resources in each country.http://dx.doi.org/10.1155/2015/596164 |
| spellingShingle | Brigid Unim Maria Assunta Veneziano Antonio Boccia Walter Ricciardi Giuseppe La Torre Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On-Demand The Scientific World Journal |
| title | Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On-Demand |
| title_full | Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On-Demand |
| title_fullStr | Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On-Demand |
| title_full_unstemmed | Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On-Demand |
| title_short | Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On-Demand |
| title_sort | haemophilia a pharmacoeconomic review of prophylaxis treatment versus on demand |
| url | http://dx.doi.org/10.1155/2015/596164 |
| work_keys_str_mv | AT brigidunim haemophiliaapharmacoeconomicreviewofprophylaxistreatmentversusondemand AT mariaassuntaveneziano haemophiliaapharmacoeconomicreviewofprophylaxistreatmentversusondemand AT antonioboccia haemophiliaapharmacoeconomicreviewofprophylaxistreatmentversusondemand AT walterricciardi haemophiliaapharmacoeconomicreviewofprophylaxistreatmentversusondemand AT giuseppelatorre haemophiliaapharmacoeconomicreviewofprophylaxistreatmentversusondemand |