DNMT3B promotes the progression of pheochromocytoma by mediating the hypermethylation of LRP1B promoter

DNMT3B promotes the progression of pheochromocytoma by mediating the hypermethylation of LRP1B promoter

Abstract Background Pheochromocytoma (Pheo) represents a potential metastatic neuroendocrine tumor. As a tumor suppressor gene, LRP1B is involved in the regulation of tumor progression. However, the precise regulatory mechanism of LRP1B in Pheo remains elusive. Methods RT-QPCR, western blot and immu...

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Bibliographic Details
Main Authors: Min Sun, Yanrong Ma, Jing Wan, Bingli Zheng, Zhenfeng Shi, Jiuzhi Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Epigenetics & Chromatin
Subjects:
Pheochromocytoma
LRP1B
DNA methylation
DNMT3B
Online Access:https://doi.org/10.1186/s13072-025-00592-8
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https://doi.org/10.1186/s13072-025-00592-8

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