ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer

ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer

Abstract Background Tumor cells can resist chemotherapy-induced pyroptosis through glycolytic reprogramming. Estrogen-related receptor alpha (ERRα) is a central regulator of cellular energy metabolism associated with poor cancer prognosis. Herein, we refine the oncogenic role of ERRα in the pyroptos...

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Bibliographic Details
Main Authors: Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Endometrial cancer
Pyroptosis
Metabolic reprogramming
ERRα
Cisplatin resistance
Online Access:https://doi.org/10.1186/s13046-023-02834-7
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https://doi.org/10.1186/s13046-023-02834-7

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