Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials
Background. Radical prostatectomy is an effective treatment for clinically localized prostate cancer. The three approaches in current use have been extensively compared in observational studies, which have methodological limitations. Objective. To compare the efficacy and safety of three radical pro...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2013/105651 |
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| author | Carolina Sandoval Salinas Andrés L. González Rangel Juan G. Cataño Cataño Juan C. Fuentes Pachón Juan S. Castillo Londoño |
| author_facet | Carolina Sandoval Salinas Andrés L. González Rangel Juan G. Cataño Cataño Juan C. Fuentes Pachón Juan S. Castillo Londoño |
| author_sort | Carolina Sandoval Salinas |
| collection | DOAJ |
| description | Background. Radical prostatectomy is an effective treatment for clinically localized prostate cancer. The three approaches in current use have been extensively compared in observational studies, which have methodological limitations. Objective. To compare the efficacy and safety of three radical prostatectomy approaches in patients with localized prostate cancer: open, laparoscopic, and robotic-assisted laparoscopic surgery. Materials and Methods. A systematic review of the literature was carried out. Databases MEDLINE, EMBASE, LILACS, and CENTRAL were searched for randomized clinical trials that directly compared two or more radical prostatectomy approaches. Selection criteria, methodological rigor, and risk of bias were evaluated by two independent researchers using Cochrane Collaboration’s tools. Results. Three trials were included. In one study, laparoscopic surgery was associated with fewer blood loss and transfusion rates than the open procedure, in spite of longer operating time. The other two trials compared laparoscopic and robotic-assisted surgery in which no differences in perioperative outcomes were detected. Nevertheless, robotic-assisted prostatectomy showed more favorable erectile function and urinary continence recovery. Conclusion. At the present time, no clear advantage can be attributed to any of the existing prostatectomy approaches in terms of oncologic outcomes. However, some differences in patient-related outcomes favor the newer methods. Larger trials are required. |
| format | Article |
| id | doaj-art-9c9d7416fceb43aa85074df17fe3d27e |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-9c9d7416fceb43aa85074df17fe3d27e2025-02-03T06:15:14ZengWileyAdvances in Urology1687-63691687-63772013-01-01201310.1155/2013/105651105651Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical TrialsCarolina Sandoval Salinas0Andrés L. González Rangel1Juan G. Cataño Cataño2Juan C. Fuentes Pachón3Juan S. Castillo Londoño4Grupo de Investigación Clínica, Instituto Nacional de Cancerología, Calle 1 No. 9-85, Bogotá, DC 110321-012, ColombiaGrupo de Investigación Clínica, Instituto Nacional de Cancerología, Calle 1 No. 9-85, Bogotá, DC 110321-012, ColombiaCentro Oncológico Javeriano, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Carrera 7 No. 40-62, Bogotá, DC 110311-066, ColombiaGrupo de Investigación Clínica, Instituto Nacional de Cancerología, Calle 1 No. 9-85, Bogotá, DC 110321-012, ColombiaGrupo de Investigación Clínica, Instituto Nacional de Cancerología, Calle 1 No. 9-85, Bogotá, DC 110321-012, ColombiaBackground. Radical prostatectomy is an effective treatment for clinically localized prostate cancer. The three approaches in current use have been extensively compared in observational studies, which have methodological limitations. Objective. To compare the efficacy and safety of three radical prostatectomy approaches in patients with localized prostate cancer: open, laparoscopic, and robotic-assisted laparoscopic surgery. Materials and Methods. A systematic review of the literature was carried out. Databases MEDLINE, EMBASE, LILACS, and CENTRAL were searched for randomized clinical trials that directly compared two or more radical prostatectomy approaches. Selection criteria, methodological rigor, and risk of bias were evaluated by two independent researchers using Cochrane Collaboration’s tools. Results. Three trials were included. In one study, laparoscopic surgery was associated with fewer blood loss and transfusion rates than the open procedure, in spite of longer operating time. The other two trials compared laparoscopic and robotic-assisted surgery in which no differences in perioperative outcomes were detected. Nevertheless, robotic-assisted prostatectomy showed more favorable erectile function and urinary continence recovery. Conclusion. At the present time, no clear advantage can be attributed to any of the existing prostatectomy approaches in terms of oncologic outcomes. However, some differences in patient-related outcomes favor the newer methods. Larger trials are required.http://dx.doi.org/10.1155/2013/105651 |
| spellingShingle | Carolina Sandoval Salinas Andrés L. González Rangel Juan G. Cataño Cataño Juan C. Fuentes Pachón Juan S. Castillo Londoño Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials Advances in Urology |
| title | Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials |
| title_full | Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials |
| title_fullStr | Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials |
| title_full_unstemmed | Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials |
| title_short | Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials |
| title_sort | efficacy of robotic assisted prostatectomy in localized prostate cancer a systematic review of clinical trials |
| url | http://dx.doi.org/10.1155/2013/105651 |
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