Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells

Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells

Glutamine metabolism is emerging as a target for improving immunotherapy efficacy. However, the outcomes remain inconclusive. Given that the tumor-intrinsic response to interferon-γ (IFN-γ) is a key determinant of immunotherapy efficacy, we investigated whether and how glutamine deprivation in cance...

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Bibliographic Details
Main Authors: Zhiwei Yuan, Taiyan Yu, Xu Wang, Kelin Meng, Tianlai Wang, Boyu Wang, Yu Xi, Congjian Wang, Chenxi Zeng, Shaojie Hu, Yitao Tian, Hui Xiong, Qi Wang, Wenbin Zou, Xue Wang, Yi Gao, Xiangning Fu, Lequn Li
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Pharmacological Research
Subjects:
Glutamine metabolism
IFN-γ signaling
Non-small cell lung cancer
Autophagy
Immunotherapy
V9302
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000684
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