Repeated naloxone-induced morphine withdrawal alters blood brain barrier and blood spinal cord barrier integrity in mice

Abstract Passage of molecules across the central nervous system is tightly regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), which restrict entry of many substances, including opioid medications. Here, we examined the effects of opioid withdrawal on BBB and BSCB integr...

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Bibliographic Details
Main Authors: Yuta Kohro, Craig E. Brown, Tuan Trang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Brain
Subjects:
Online Access:https://doi.org/10.1186/s13041-025-01231-9
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