Reactive oxygen species regulate adipose-osteogenic lineage commitment of human mesenchymal stem cells by modulating gene expression of C/EBP homology protein and aldo-keto reductase family 1 member A1

Reactive oxygen species regulate adipose-osteogenic lineage commitment of human mesenchymal stem cells by modulating gene expression of C/EBP homology protein and aldo-keto reductase family 1 member A1

Abstract Background Bone-derived mesenchymal stem cells (BMSCs) are multipotent stem cells capable of differentiating into adipocytes and osteoblasts. Dysfunctional differentiation, characterized by a shift from osteoblastogenesis to adipogenesis, is closely associated with metabolic and senile oste...

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Main Authors: Chen Hao Chiang, Yu-Chieh Kao, Yi-Hui Lin, Yi-Shing Ma, Yu-Ting Wu, Bo-Yan Jian, Yau-Huei Wei, Chuan-Mu Chen, Ying-Ming Liou
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell & Bioscience
Subjects:
Aldo-keto reductase family 1 member A1 (Akr1A1)
Mesenchymal stem cells
Peroxisome-proliferator-activated receptor γ coactivator-1α (PGC-1α)
Silent mating type information regulation 2 homolog 1 (SIRT1)
Osteogenesis
Online Access:https://doi.org/10.1186/s13578-025-01448-0
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https://doi.org/10.1186/s13578-025-01448-0

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