Novel loop structure of human IgG1 Fc fused CD38 targeted bispecific antibodies and their anti-tumor effect in acute myeloid leukemia

Novel loop structure of human IgG1 Fc fused CD38 targeted bispecific antibodies and their anti-tumor effect in acute myeloid leukemia

Abstract Background Acute myeloid leukemia (AML) still lacks an ideal immunotherapy target. CD38 serves as a potential therapeutic target for AML. Classical bispecific antibody (BsAb) requires continuous infusion due to small molecular size and short half-life. Methods The anti-human CD38 single-cha...

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Main Authors: Shisen Wang, Manling Chen, Tong Zhou, Chengcai Guo, Zhifeng Yan, Yingxi Xu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Shaowei Qiu, Ying Wang, Runxia Gu, Min Wang, Jianxiang Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
CD38
Bispecific antibody
Immunotherapy
Acute myeloid leukemia
Online Access:https://doi.org/10.1186/s12967-025-06827-2
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https://doi.org/10.1186/s12967-025-06827-2

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