Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity

Plant-derived nanovesicles have gained attention given their similarity to mammalian exosomes and advantages such as low cost, sustainability, and tissue targeting. Thus, they hold promise for disease treatment and drug delivery. In this study, we proposed a time-efficient method, PEG 8000 combined...

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Main Authors: Shengjie Huang, Min Zhang, Xiaoge Li, Jierong Pei, Zhirong Zhou, Peng Lei, Meng Wang, Peng Zhang, Heshui Yu, Guanwei Fan, Lifeng Han, Haiyang Yu, Yuefei Wang, Miaomiao Jiang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Pharmaceutical Analysis
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Online Access:http://www.sciencedirect.com/science/article/pii/S2095177924001114
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author Shengjie Huang
Min Zhang
Xiaoge Li
Jierong Pei
Zhirong Zhou
Peng Lei
Meng Wang
Peng Zhang
Heshui Yu
Guanwei Fan
Lifeng Han
Haiyang Yu
Yuefei Wang
Miaomiao Jiang
author_facet Shengjie Huang
Min Zhang
Xiaoge Li
Jierong Pei
Zhirong Zhou
Peng Lei
Meng Wang
Peng Zhang
Heshui Yu
Guanwei Fan
Lifeng Han
Haiyang Yu
Yuefei Wang
Miaomiao Jiang
author_sort Shengjie Huang
collection DOAJ
description Plant-derived nanovesicles have gained attention given their similarity to mammalian exosomes and advantages such as low cost, sustainability, and tissue targeting. Thus, they hold promise for disease treatment and drug delivery. In this study, we proposed a time-efficient method, PEG 8000 combined with sucrose density gradient centrifugation to prepare ginger-derived nanovesicles (GDNVs). Subsequently, curcumin (CUR) was loaded onto GDNV by ultrasonic incubation. The optimum conditions for ginger-derived nanovesicles loaded with curcumin (CG) were ultrasound time of 3 min, a carrier-to-drug ratio (GDNV:CUR) of 1:1. The study achieved a high loading capacity (94.027% ± 0.094%) and encapsulation efficiency (89.300% ± 0.344%). Finally, the drugs' in vivo distribution and anti-colitis activity were investigated in mice. CG was primarily distributed in the colon after oral administration. Compared to CUR and GDNV, CG was superior in improving disease activity, colon length, liver and spleen coefficients, myeloperoxidase activity, and biochemical factor levels in ulcerative colitis (UC) mice. In addition, CG plays a protective role against UC by modulating serum metabolite levels and gut flora. In summary, our study demonstrated that GDNV can be used for CUR delivery with enhanced therapeutic potential.
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spelling doaj-art-9c6585a969b748b1aa400f29dbafc1c52025-01-30T05:13:58ZengElsevierJournal of Pharmaceutical Analysis2095-17792024-12-011412101014Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activityShengjie Huang0Min Zhang1Xiaoge Li2Jierong Pei3Zhirong Zhou4Peng Lei5Meng Wang6Peng Zhang7Heshui Yu8Guanwei Fan9Lifeng Han10Haiyang Yu11Yuefei Wang12Miaomiao Jiang13National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, ChinaNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, China; Corresponding author. National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.Plant-derived nanovesicles have gained attention given their similarity to mammalian exosomes and advantages such as low cost, sustainability, and tissue targeting. Thus, they hold promise for disease treatment and drug delivery. In this study, we proposed a time-efficient method, PEG 8000 combined with sucrose density gradient centrifugation to prepare ginger-derived nanovesicles (GDNVs). Subsequently, curcumin (CUR) was loaded onto GDNV by ultrasonic incubation. The optimum conditions for ginger-derived nanovesicles loaded with curcumin (CG) were ultrasound time of 3 min, a carrier-to-drug ratio (GDNV:CUR) of 1:1. The study achieved a high loading capacity (94.027% ± 0.094%) and encapsulation efficiency (89.300% ± 0.344%). Finally, the drugs' in vivo distribution and anti-colitis activity were investigated in mice. CG was primarily distributed in the colon after oral administration. Compared to CUR and GDNV, CG was superior in improving disease activity, colon length, liver and spleen coefficients, myeloperoxidase activity, and biochemical factor levels in ulcerative colitis (UC) mice. In addition, CG plays a protective role against UC by modulating serum metabolite levels and gut flora. In summary, our study demonstrated that GDNV can be used for CUR delivery with enhanced therapeutic potential.http://www.sciencedirect.com/science/article/pii/S2095177924001114CurcuminGinger derived nanovesicles loaded with curcuminUlcerative colitisMetabolomicsIntestinal flora
spellingShingle Shengjie Huang
Min Zhang
Xiaoge Li
Jierong Pei
Zhirong Zhou
Peng Lei
Meng Wang
Peng Zhang
Heshui Yu
Guanwei Fan
Lifeng Han
Haiyang Yu
Yuefei Wang
Miaomiao Jiang
Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity
Journal of Pharmaceutical Analysis
Curcumin
Ginger derived nanovesicles loaded with curcumin
Ulcerative colitis
Metabolomics
Intestinal flora
title Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity
title_full Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity
title_fullStr Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity
title_full_unstemmed Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity
title_short Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity
title_sort formulation characterization and evaluation of curcumin loaded ginger derived nanovesicles for anti colitis activity
topic Curcumin
Ginger derived nanovesicles loaded with curcumin
Ulcerative colitis
Metabolomics
Intestinal flora
url http://www.sciencedirect.com/science/article/pii/S2095177924001114
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