Modulation of CCR5 expression and R5 HIV-1 infection in primary macrophages exposed to sera from HESN, LTNP, and chronically HIV-1 infected people with or without natural antibodies to CCR5

Modulation of CCR5 expression and R5 HIV-1 infection in primary macrophages exposed to sera from HESN, LTNP, and chronically HIV-1 infected people with or without natural antibodies to CCR5

CCR5 is the main co-receptor for HIV-1 cell entry and it plays key roles in HIV-1 mucosal transmission. Natural anti-CCR5 antibodies were found in HIV-1-exposed seronegative and long-term non-progressor subjects, suggesting a role in controlling viral replication in vivo. We assessed the effect of s...

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Main Authors: Iole Farina, Mauro Andreotti, Claudia Pastori, Roberta Bona, Clementina Maria Galluzzo, Roberta Amici, Cristina Purificato, Caterina Uberti-Foppa, Agostino Riva, Maria Cristina Gauzzi, Lucia Lopalco, Laura Fantuzzi
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Virus Research
Subjects:
HIV-1
Natural anti-CCR5 antibody
Primary macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170224001990
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