Prophage induction is enhanced and required for renal disease and lethality in an EHEC mouse model.

Prophage induction is enhanced and required for renal disease and lethality in an EHEC mouse model.

Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. A...

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Main Authors: Jessica S Tyler, Karen Beeri, Jared L Reynolds, Christopher J Alteri, Katherine G Skinner, Jonathan H Friedman, Kathryn A Eaton, David I Friedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003236&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003236&type=printable

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