The development of functional opsonophagocytic assays to evaluate antibody responses to Klebsiella pneumoniae capsular antigens

The development of functional opsonophagocytic assays to evaluate antibody responses to Klebsiella pneumoniae capsular antigens

ABSTRACT Klebsiella pneumoniae is one of the leading causes of nosocomial infections in low- and middle-income countries (LMICs), with a high mortality rate among the immunocompromised. With increasing antibiotic resistance, there is an urgent need for preventive measures such as vaccines, but none...

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Main Authors: Robert Lawrence, Emma Bownes, Marina Johnson, Heather Fox, Drew Huff, Ivan Olave, Anup Datta, David Goldblatt, Nathalie Karaky
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mSphere
Subjects:
Klebsiella pneumoniae
vaccines
opsonophagocytic killing assay
K antigen
capsule
Online Access:https://journals.asm.org/doi/10.1128/msphere.00176-25
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https://journals.asm.org/doi/10.1128/msphere.00176-25

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