SOX combined with tislelizumab and low-dose radiation therapy for the neoadjuvant treatment of locally advanced gastric/gastroesophageal junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase Ib/II clinical trial

SOX combined with tislelizumab and low-dose radiation therapy for the neoadjuvant treatment of locally advanced gastric/gastroesophageal junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase Ib/II clinical trial

BackgroundRecently, the clinical benefits of neoadjuvant chemotherapy combined with immunotherapy have been observed in patients with locally advanced gastric or gastroesophageal junction (G/GEJ) cancer; however, the pathological complete response (pCR) and long-term survival rates are still unsatis...

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Bibliographic Details
Main Authors: Peng-Fei Zhang, Ye Chen, Wen-Ke Li, Zhu-Mei Luo, Ji Chen, Kun Qian, Xiao-Dong Chen, Mo-Jin Wang, Ming Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
gastric cancer
neoadjuvant therapy
S-1
oxaliplatin
tislelizumab
low-dose radiation therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1431957/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1431957/full

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