Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a

Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a

Malaria remains a major public health concern. The rapid spread of resistance to antimalarial drugs is a major challenge for malaria eradication. Timely and accurate molecular monitoring based on practical detection methods is a critical step toward malaria control and elimination. In this study, tw...

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Main Authors: Huiyin Zhu, Daiqian Zhu, Yuting Li, Yun Li, Xiaonan Song, Jinyu Mo, Long Liu, Zhixin Liu, Siqi Wang, Yi Yao, He Yan, Kai Wu, Wei Wang, Jianhai Yin, Min Lin, Jian Li
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Plasmodium falciparum
Single nucleotide polymorphism
Pfexo gene
Allele-specific PCR
Recombinase-aided amplification
CRISPR/Cas12a
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320724000496
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