Exploring Multivalent Architectures for Binding and Stabilization of <i>N</i>-Acetylgalactosamine 6-Sulfatase

Exploring Multivalent Architectures for Binding and Stabilization of <i>N</i>-Acetylgalactosamine 6-Sulfatase

Morquio A syndrome is a lysosomal disorder caused by the deficiency of the lysosomal enzyme <i>N</i>-acetylgalactosamine 6-sulfatase (GALNS, EC 3.1.6.4). Currently, enzyme replacement therapy (ERT) is used to treat Morquio A through the infusion of the recombinant enzyme VIMIZIM<sup&g...

Full description

Saved in:
Bibliographic Details
Main Authors: Maria Giulia Davighi, Francesca Clemente, Giampiero D’Adamio, Macarena Martínez-Bailén, Alessio Morano, Andrea Goti, Amelia Morrone, Camilla Matassini, Francesca Cardona
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
Morquio A
<i>N</i>-acetylgalactosamine 6-sulfatase
enzyme stabilizers
iminosugars
dendrimers
multivalent glycomimetics
Online Access:https://www.mdpi.com/1420-3049/30/10/2222
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1420-3049/30/10/2222

Similar Items