Steroid dynamics in myalgic encephalomyelitis / chronic fatigue syndrome: a case-control study using ultra performance supercritical fluid chromatography tandem mass spectrometry

Steroid dynamics in myalgic encephalomyelitis / chronic fatigue syndrome: a case-control study using ultra performance supercritical fluid chromatography tandem mass spectrometry

Abstract Background Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a multisystem disorder characterised by unrelenting fatigue, post-exertional malaise, and dysfunction across immune, nervous, metabolism, and endocrine systems. Given the broad role of steroid hormones in regulating...

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Bibliographic Details
Main Authors: Natalie Thomas, S. J. Kumari A. Ubhayasekera, Christopher W. Armstrong, Katherine Huang, Jonas Bergquist
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
ME/CFS
Steroidomics
Ultra-performance supercritical fluid chromatography tandem mass spectrometry (UPSFC-MS/MS)
Partial correlations
Network analysis
Neuroendocrine dysfunction
Online Access:https://doi.org/10.1186/s12967-025-06841-4
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https://doi.org/10.1186/s12967-025-06841-4

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