Exploring the Efficacy and Potential Mechanisms of Topical <i>Periplaneta americana</i> (L.) Extract in Treating Androgenetic Alopecia in a Mouse Model: A Systems Pharmacology and Skin Microbiome Analysis

Exploring the Efficacy and Potential Mechanisms of Topical <i>Periplaneta americana</i> (L.) Extract in Treating Androgenetic Alopecia in a Mouse Model: A Systems Pharmacology and Skin Microbiome Analysis

Androgenetic alopecia (AGA), the most prevalent form of hair loss worldwide, faces significant therapeutic challenges due to high costs and limited efficacy of current interventions, necessitating safer and more effective solutions. <i>Periplaneta americana</i> (L.)-derived PA-011, endow...

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Bibliographic Details
Main Authors: Tangfei Guan, Xin Yang, Canhui Hong, Peiyun Xiao, Yongshou Yang, Chenggui Zhang, Zhengchun He
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biology
Subjects:
<i>Periplaneta americana</i> (L.)
androgenic alopecia
network pharmacology
transcriptomics
non-target metabolomics
microbiota ecological balance
Online Access:https://www.mdpi.com/2079-7737/14/7/831
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