Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli

Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli

ABSTRACT The rapid spread of antibiotic resistance poses a global health crisis. Tigecycline is a last-resort antibiotic, but the recent emergence of the plasmid-borne tet(X3) gene conferring high-level tigecycline resistance is deeply concerning. Here, we report a metabolomics-guided approach to ov...

Full description

Saved in:
Bibliographic Details
Main Authors: Jing Sun, Yiming Liu, Jiashen Chang, Ying Liu, Luqi Li, Ran Jiang, Yihan Luo, Shuo Yang, Mei Yang, Xinglong Wang, Juan Wang, Xi Xia, Kangkang Guo, Zengqi Yang, Dongyang Ye
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
tet(X3)
tigecycline
adenosine
antimicrobial resistance
metabolomics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02382-24
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://journals.asm.org/doi/10.1128/spectrum.02382-24

Similar Items