ITPA POLYMORPHISMS AND THE INCIDENCE OF TOXICITIES IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

ITPA POLYMORPHISMS AND THE INCIDENCE OF TOXICITIES IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Background: 6-Mercaptopurine (6-MP), a thiopurine agent, is an indispensable medication for treating pediatric acute lymphoblastic leukemia (ALL). However, its side effects of neutropenia and hepatotoxicity might interrupt treatment, resulting in poor outcomes. Inosine triphosphate pyrophosphatase...

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Main Authors: Patpetra Svasdisant, Waraporn Glomglao, Preeyanun Siraprapapat, Wiyakan Inthararujikul, Kalaya Tachavanich, Chetsada Boonthimat, Sakkarin Ardsiri, Kochpinchon Chansing, Suwimon Sriprach, Sasima Tongsai, Phakatip Sinlapamongkolkul, Kleebsabai Sanpakit, Jassada Buaboonnam
Format: Article
Language:English
Published: PAGEPress Publications 2023-02-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
Inosine triphosphate pyrophosphatase
Leukemia
Mercaptopurine
Neutropenia
Transaminitis
Online Access:http://www.mjhid.org/index.php/mjhid/article/view/5248
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http://www.mjhid.org/index.php/mjhid/article/view/5248

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