LPM electrode loaded with RAPA-PLGA drug sustained-release system can reduce local fibrous tissue hyperplasia and local bioelectrical impedance

LPM electrode loaded with RAPA-PLGA drug sustained-release system can reduce local fibrous tissue hyperplasia and local bioelectrical impedance

Abstract Objective This study aims to design and fabricate a leadless pacemaker (LPM) electrode loaded with rapamycin (RAPA)–poly(lactic-co-glycolic acid) (PLGA) drug sustained-release system to reduce the local fibrous tissue proliferation after LPM implantation, reduce local bioelectrical impedanc...

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Bibliographic Details
Main Authors: Xiu Wang, Wentao Du, Yunyun Wang, Ahsan Riaz Khan, Haijun Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:European Journal of Medical Research
Subjects:
Leadless pacemakers
Electrode
Rapamycin
PLGA
Fibrous tissue hyperplasia
Online Access:https://doi.org/10.1186/s40001-025-02619-y
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https://doi.org/10.1186/s40001-025-02619-y

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