USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma

USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma

Abstract Background The role of post-translational modifications(PTMs) in PD-L1-mediated immune resistance and melanoma progression remains poorly understood. Methods We conducted multi-omics analyses and constructed a prognostic model based on PTM-related genes using machine learning to identify ke...

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Bibliographic Details
Main Authors: Jiaheng Xie, Pengpeng Zhang, Yuankun Liu, Dan Wu, Xueqi Ou, Ming Wang, Wei Yan, Jianlan Liu, Jian Tang, Tianyi Ni, Chenfeng Ma, Qikai Tang, Songyun Zhao, Min Qi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
USP5
PD-L1
Immune escape
Melanoma
Immunotherapy
Online Access:https://doi.org/10.1186/s12967-025-06812-9
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https://doi.org/10.1186/s12967-025-06812-9

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