CPI203, a BET inhibitor, down-regulates a consistent set of DNA synthesis genes across a wide array of glioblastoma lines.

CPI203, a BET inhibitor, down-regulates a consistent set of DNA synthesis genes across a wide array of glioblastoma lines.

<h4>Introduction</h4>Glioblastomas utilize malignant gene expression pathways to drive growth. Many of these gene pathways are not directly accessible with molecularly targeted pharmacological agents. Chromatin-modifying compounds can alter gene expression and target glioblastoma growth...

Full description

Saved in:
Bibliographic Details
Main Authors: Matthew C Garrett, Troy Carnwath, Rebecca Albano, Yonghua Zhuang, Catherine A Behrmann, Merissa Pemberton, Farah Barakat, Robert Lober, Mark Hoeprich, Anthony Paravati, Marilyn Reed, Hailey Spry, Daniel Woo, Eric O'Brien, Brett VanCauwenbergh, John Perentesis, Rani Nasser, Mario Medvedovic, David R Plas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0306846
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.pone.0306846

Similar Items