F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair

Abstract Scarring is an insurmountable obstacle for axonal regeneration in recovery from spinal cord injury (SCI). It impedes the repair effects of therapeutic targets in cortical neurons, such as PTEN−/− and hyper-IL-6, which cannot break through dense scar barriers to reconstruct neural circuits....

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Main Authors: Xu Xu, Feng Gao, Qixin Chen, Bairu Chen, Wenyu Liang, Runzhi Huang, Yuchen Liu, Zhibo Liu, Yanjing Zhu, Gufa Lin, Bei Ma, Letao Yang, Shaorong Gao, Rongrong Zhu, Liming Cheng
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02354-0
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